Clinical Investigations

Omniscient Neurotechnology collaborates with clinical institutes across the world to perform investigations into uncommon disorders of the brain and how connectomics can best be applied pre- and post-surgically to ascribe symptom origination, surgical planning, and post-surgical improvement. Our Quicktome software for neurosurgeons and Infinitome software for researchers provides various output metrics that are presented in these publications

 

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{id=49309328900, createdAt=1624436076303, 1='{type=string, value=A Connectivity Model of the Anatomic Substrates Underlying Ideomotor Apraxia A Meta-Analysis of Functional Neuroimaging Studies}', 2='{type=list, value=[{id=13, name='fMRI', order=0}, {id=14, name='DTI', order=1}, {id=15, name='Neurosurgery', order=2}, {id=18, name='Connectomics', order=5}, {id=22, name='Quicktome', order=9}]}', 3='{type=string, value=https://www.o8t.com/hubfs/Clinical%20Papers/A%20%20Connectivity%20%20Model%20%20of%20%20the%20%20Anatomic%20%20Substrates%20Underlying%20%20Ideomotor%20%20Apraxia%20%20A%20%20Meta-Analysisof%20%20Functional%20%20Neuroimaging%20%20Studies.pdf}', 4='{type=image, value=Image{width=435, height=320, url='https://www.o8t.com/hubfs/ResearchPageImage_26.jpg'}}', 5='{type=string, value=Patients with ideomotor apraxia (IMA) present with selective impairments in higher-order motor cognition and execution without damage to any motor or sensory pathways. Although extensive research has been conducted to determine the regions of interest (ROIs) underlying these unique impairments, previous models are heterogeneous and may be further clarified based on their structural connectivity, which has been far less described. }', 7='{type=list, value=[{id=9, name='Clinical investigation', order=2}]}', 8='{type=number, value=1623715200000}', 9='{type=number, value=0}'}

A Connectivity Model of the Anatomic Substrates Underlying Ideomotor Apraxia A Meta-Analysis of Functional Neuroimaging Studies

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{id=48432884542, createdAt=1622940032946, 1='{type=string, value=The Frontal Aslant Tract and Supplementary Motor Area Syndrome: Moving towards a Connectomic Initiation Axis}', 2='{type=list, value=[{id=15, name='Neurosurgery', order=2}, {id=16, name='Brain Tumor', order=3}, {id=18, name='Connectomics', order=5}]}', 3='{type=string, value=https://www.o8t.com/hubfs/Clinical%20Papers/The%20Frontal%20Aslant%20Tract%20and%20Supplementary%20Motor%20Area%20Syndrome%20Moving%20towards%20a%20Connectomic%20Initiation%20Axis.pdf}', 4='{type=image, value=Image{width=435, height=320, url='https://www.o8t.com/hubfs/ResearchPageImage_20.jpg'}}', 5='{type=string, value=Damage to the superior frontal gyrus during frontal lobe surgery is thought to induce supplementary motor area (SMA) syndrome in patients. However, network-based modeling may provide a more accurate cortical model of SMA syndrome, including the Frontal Aslant Tract (FAT). }', 7='{type=list, value=[{id=9, name='Clinical investigation', order=2}]}', 8='{type=number, value=1614902400000}', 9='{type=number, value=0}'}

The Frontal Aslant Tract and Supplementary Motor Area Syndrome: Moving towards a Connectomic Initiation Axis

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{id=48432865409, createdAt=1622939833995, 1='{type=string, value=Pure Apraxia of Speech After Resection Based in the Posterior Middle Frontal Gyrus}', 2='{type=list, value=[{id=15, name='Neurosurgery', order=2}, {id=16, name='Brain Tumor', order=3}]}', 3='{type=string, value=https://www.o8t.com/hubfs/Clinical%20Papers/Pure%20Apraxia%20of%20speech%20after%20resection%20based%20in%20the%20posterior%20middle%20frontal%20gyrus.pdf}', 4='{type=image, value=Image{width=435, height=320, url='https://www.o8t.com/hubfs/ResearchPageImage_18.jpg'}}', 5='{type=string, value=Apraxia of speech is a disorder of articulatory coordination and planning in speech sound production. Its diagnosis is based on deficits in articulation, prosody, and fluency. It is often described concurrent with aphasia or dysarthria, while pure apraxia of speech is a rare entity}', 7='{type=list, value=[{id=9, name='Clinical investigation', order=2}]}', 8='{type=number, value=1598918400000}', 9='{type=number, value=0}'}

Pure Apraxia of Speech After Resection Based in the Posterior Middle Frontal Gyrus

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{id=48433186140, createdAt=1622940220154, 1='{type=string, value=Bilateral carotid-cavernous fistulas treated with partial embolization and radiosurgery}', 2='{type=list, value=[{id=15, name='Neurosurgery', order=2}]}', 3='{type=string, value=https://www.o8t.com/hubfs/Clinical%20Papers/Bilateral%20carotid-cavernous%20fistulas%20treated%20with%20partial%20embolization%20and%20radiosurgery.pdf}', 4='{type=image, value=Image{width=435, height=320, url='https://www.o8t.com/hubfs/ResearchPageImage_21.jpg'}}', 5='{type=string, value=Bilateral carotid-cavernous fistulas (CCFs) are rare. In this paper, we report the case of an 88- year-old woman who presented with a two-month history of worsening visual symptoms and was subsequently found to have bilateral Barrow grade D CCFs. Cannulation and complete embolization of the offending vessels during angiography proved unsuccessful, and so the patient underwent adjuvant radiosurgery as salvage therapy with a good clinical outcome. This case adds to the limited but growing literature on the multi-modal management of CCFs.}', 7='{type=list, value=[{id=9, name='Clinical investigation', order=2}]}', 8='{type=number, value=1570665600000}', 9='{type=number, value=0}'}

Bilateral carotid-cavernous fistulas treated with partial embolization and radiosurgery

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{id=48433160784, createdAt=1622939933662, 1='{type=string, value=The crossed frontal aslant tract: a possible pathway involved in the recovery of supplementary motor area syndrome}', 2='{type=list, value=[{id=15, name='Neurosurgery', order=2}, {id=16, name='Brain Tumor', order=3}]}', 3='{type=string, value=https://www.o8t.com/hubfs/Clinical%20Papers/The%20crossed%20frontal%20aslant%20tract%20a%20possible%20pathway%20involved%20in%20the%20recovery%20of%20supplementary%20motor%20area%20syndrome.pdf}', 4='{type=image, value=Image{width=435, height=320, url='https://www.o8t.com/hubfs/ResearchPageImage_19.jpg'}}', 5='{type=string, value=Supplementary motor area (SMA) syndrome is a constellation of temporary symptoms that may occur following tumors of the frontal lobe. Affected patients develop akinesia and mutism but often recover within weeks to months. With our own case examples and with correlations to fiber tracking validated by gross anatomical dissection as ground truth, we describe a white matter pathway through which recovery may occur}', 7='{type=list, value=[{id=9, name='Clinical investigation', order=2}]}', 8='{type=number, value=1512518400000}', 9='{type=number, value=0}'}

The crossed frontal aslant tract: a possible pathway involved in the recovery of supplementary motor area syndrome

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