Clinical Investigations

Omniscient Neurotechnology collaborates with clinical institutes across the world to perform investigations into uncommon disorders of the brain and how connectomics can best be applied pre- and post-surgically to ascribe symptom origination, surgical planning, and post-surgical improvement. Our Quicktome software for neurosurgeons and Infinitome software for researchers provides various output metrics that are presented in these publications


A connectivity model of the anatomic substrates underlying Gerstmann syndrome

June 14, 2022

Gerstmann syndrome is a neurological phenomena associated with a variety of motor and cognitive deficits. From a large clinical dataset, we identify brain networks compromised in this syndrome.

Interventional neurorehabilitation for promoting functional recovery post‑craniotomy: a proof‑of‑concept

February 23, 2022

A proof-of-concept study demonstrating the capability of o8t software in generating personalized TMS targets for post-craniotomy neurorehabilitation

A Connectivity Model of the Anatomic Substrates Underlying Ideomotor Apraxia A Meta-Analysis of Functional Neuroimaging Studies

June 15, 2021

A meta-analysis revealing the network constitutents of ideomotor apraxia. We present a connectivity model to explain the determinants of this condition.

Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation

April 6, 2021

A case study highlighting the benefits of transcranial magnetic stimulation for restoring network functional connectivity in the DMN.

Targeting location relates to treatment response in active but not sham rTMS stimulation

April 1, 2021

A re-opened investigation utilizing o8t atlassing revealed that inaccurate targeting of the dlPFC in veterans reduced treatment response.

Application of structural and functional connectome mismatch for classification and individualized therapy for Alzheimers disease

November 23, 2020

By utilizing the o8t Infinitome processing pipeline, this study revealed connectomic anomalies in the Default Mode Network (DMN) which underpinned the progression of Alzheimer's Disease.

Bilateral carotid-cavernous fistulas treated with partial embolization and radiosurgery

October 10, 2019

This manuscript presents a case report, treatment strategy, and subsequent outcomes of a patient suffering a rare bilateral carotid-cavernous fistula (CCF).

The crossed frontal aslant tract: a possible pathway involved in the recovery of supplementary motor area syndrome

December 6, 2017

We present a novel hypothesis for the manifestation of Supplementary Motor Area (SMA) syndrome: that damaging the crossed frontal aslant tract subsists this neurosurgical consequence.