CONNECTOMICS, NOW CODED.
Effective July 1, 2026
Defining the standard for connectomic analysis
The American Medical Association (AMA) has issued a new Category III CPT® code, X529T, recognizing the unique clinical value of connectomic analysis. This new code provides a distinct pathway for physicians to report the advanced analysis required to map brain networks, separating it from standard MRI interpretation.
This milestone validates what we at Omniscient have known from the start: decoding the brain’s intricate wiring is essential for the future of patient care.
The code for connectivity
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A reimbursement milestone
Clinical Validation The issuance of X529T moves connectomics from the research realm to a recognized clinical procedure. It validates the necessity and utility of the mapping and analysis of an individual’s intricate web of brain connections and functions to inform treatment and prognosis.
Roadmap to Reimbursement As a Category III "tracking code," X529T is the essential first step toward permanent Category I status. By utilizing this code, you contribute to the data set that will determine future payment rates and coverage policies.
Workflow Standardization This code formalizes the workflow for advanced brain mapping and connectomics, allowing you to document the time and expertise you invest in optimizing your patient’s outcomes.
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Omniscient advocated for this CPT code to accurately reflect the connectomic analysis workflow enabled by Quicktome.
Automated Integration Quicktome® leverages AI to automatically decode and map the brain’s networks using just a straightforward MRI scan, eliminating manual processing steps.
Interactive Planning Our FDA-cleared, web-based platform enables the "physician interaction" required by the code, enabling you to manipulate maps, assess patient connectivity, and export clinically necessary images.
frequently asked questions
Q: What is a CPT® Category III code?
A: Category III codes are temporary codes for emerging technologies, services, and procedures. They are used to track utilization and collect data to support eventual conversion to a permanent Category I code (standard reimbursement). Since unlisted codes cannot track specific data, the AMA requires providers to use Category III codes whenever possible.
Q: How do I get paid for X529T?
A: Because CPT code X529T (effective July 1, 2026) is a new Category III tracking code, it does not yet have a nationally established Relative Value Unit (RVU) or fee schedule. While not guaranteed, the existence of the code allows you to negotiate with payers and submit claims for the distinct service provided. Instead, payers will determine reimbursement amounts through Individual Consideration—a process where payment is assessed on a claim-by-claim basis rather than a fixed rate. To secure appropriate payment, clinicians and billing teams must proactively "build the case" for the service's value in each claim. Submitting robust documentation that details the physician’s time and the high cognitive complexity of interpreting connectomic data can be helpful, as can "cross-walking" the service to comparable established codes (such as functional mapping) to provide a pricing benchmark. Additionally, providing invoices for the technical costs of the Quicktome® platform may help justify the expense to payers.
Feel free to use this draft Letter of Medical Necessity template as a starting point for your Individual Consideration.
Q: Can this be billed in addition to standard MRI codes?
A: Yes, X529T is for the analysis of previously performed MRI and can be reported separately from the imaging. However, it should not be reported in conjunction with certain codes like 70551-70553 or 76376/76377 on the same date of service for the same purpose. Consult the CPT® Manual for specifics.
Q: When will the new CPT code go into effect?
A: CPT X529T will be effective July 1, 2026.
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