--- title: Research | Omniscient image: https://www.o8t.com/hubfs/iStock-2160715241.jpg --- [![o8t_omniscient_Logo_RGB_Horizontal_MONO](https://www.o8t.com/hs-fs/hubfs/Omni_Logos/o8t_omniscient_Logo_RGB_Horizontal_MONO.png?width=174&height=48&name=o8t_omniscient_Logo_RGB_Horizontal_MONO.png) ![o8t_omniscient_Logo_RGB_Horizontal_REV_8000px](https://www.o8t.com/hs-fs/hubfs/o8t_omniscient_Logo_RGB_Horizontal_REV_8000px.png?width=174&height=39&name=o8t_omniscient_Logo_RGB_Horizontal_REV_8000px.png) ](https://www.o8t.com/?hsLang=en) [ Request a Demo ](https://www.o8t.com/book-a-demo?hsLang=en) [![o8t_omniscient_Logo_RGB_Horizontal_REV_8000px](https://www.o8t.com/hs-fs/hubfs/o8t_omniscient_Logo_RGB_Horizontal_REV_8000px.png?width=174&height=39&name=o8t_omniscient_Logo_RGB_Horizontal_REV_8000px.png) ](https://www.o8t.com/?hsLang=en) [ Request a Demo ](https://www.o8t.com/book-a-demo?hsLang=en) ## Research & Publications ##### Omniscient Neurotechnology conducts independent and collaborative research with institutions around the world. We provide insight into neuropathology through advanced brain mapping and connectomic analyses. Featured Clinical investigation March 8, 2024  | [PDF](https://www.o8t.com/research#) [Eloquent noneloquence: redefinition of cortical eloquence based on outcomes of superficial cerebral cavernous malformation resection](https://www.o8t.com/hubfs/Clinical%20Papers/Eloquent%20noneloquence%20-%20redefinition%20of%20cortical%20eloquence.pdf?hsLang=en) Clinical investigation October 1, 2023  | [PDF](https://www.o8t.com/research#) [Incorporation of Brain Connectomics for Stereotactic Radiosurgery Treatment Planning](https://www.o8t.com/hubfs/Clinical%20Papers/Sheehan%20-%20Incorporation%20of%20Brain%20Connectomics%20for%20Stereotactic%20Radiosurgery%20Treatment%20Planning%202023.pdf?hsLang=en) ## All research articles Filter by category Filter by category CATEGORY - fMRI - DTI - Neuropathology - Brain Tumor - Mental Illness - Connectomics - Machine-learning - Quicktome Displaying 1-9 of a total 98 articles. No data to display Clinical investigation September 1, 2026 [PDF](https://www.o8t.com/research#) ###### [Targeting grasp-related cortical areas for intracortical brain-machine interfaces](https://www.o8t.com/hubfs/Clinical%20Papers/Targeting%20grasp-related%20cortical%20areas%20for%20intracortical%20brain-machine%20interfaces.pdf?hsLang=en) A case report highlighting the use of Quicktome to inform intracortical electrode placement in a patient with spinal cord injury. Clinical investigation January 9, 2026 [PDF](https://www.o8t.com/research#) ###### [Eloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/2026_NavarroOlvera_EloquentGliomaResection.pdf?hsLang=en) This case report presents the first Latin American case of using Quicktome connectome-guided neuronavigation combined with awake mapping to safely resect a motor-eloquent WHO grade 2 diffuse... Clinical investigation January 1, 2026 [PDF](https://www.o8t.com/research#) ###### [Anomaly changes in the functional connectome of post-operative neurosurgical patients: A case series](https://www.o8t.com/hubfs/Clinical%20Papers/Anomaly%20changes%20in%20the%20functional%20connectome%20of%20post-operative%20neurosurgical%20patients-%20A%20case%20series.pdf?hsLang=en) A four-patient University of Miami case series using Quicktome to generate pre- and post-operative functional connectomes showed that clinical changes correlated with parcel-specific network... Clinical investigation December 19, 2025 [PDF](https://www.o8t.com/research#) ###### [Connectomics in brain tumor surgery: large-scale clinical feasibility and hypothesis-generating tractometry findings](https://www.o8t.com/hubfs/Clinical%20Papers/Sistiaga%202026%20Connectomics%20in%20brain%20tumor%20surgery%20large-scale%20clinical%20feasibility.pdf?hsLang=en) This Northwell retrospective study of 192 consecutive brain tumor surgeries demonstrated the feasibility of routinely integrating Quicktome connectomic mapping into preoperative planning with stable... Clinical investigation January 25, 2025 [PDF](https://www.o8t.com/research#) ###### [Enhancing brain tumor surgery precision with multimodal connectome imaging: Structural and functional connectivity in language-dominant areas](https://www.o8t.com/hubfs/Clinical%20Papers/Shah%20et%20al.%2c%202025%20-%20Enhancing%20brain%20tumor%20surgery%20precision.pdf?hsLang=en) Multimodal connectome imaging may enhance brain tumor surgery by providing structural and functional connectivity insights, aiding in precise resection while preserving language function. This case... ### Subscribe for important news and updates We're committed to your privacy. We uses the information you provide to us to contact you about our relevant content, products, and services. You may unsubscribe from these communications at any time. For more information, check out our **[privacy policy](https://www.o8t.com/privacy-policy?hsLang=en)**. Clinical investigation January 4, 2025 [PDF](https://www.o8t.com/research#) ###### [Connectome imaging to facilitate preservation of the frontal aslant tract](https://www.o8t.com/hubfs/Clinical%20Papers/Shah%20et%20al.%2c%202025%20-%20Connectome%20Imaging.pdf?hsLang=en) Connectome imaging was used to assist in preserving the frontal aslant tract (FAT) during tumor resection. This case study highlights the role of preoperative tractography in reducing the risk of... Clinical investigation March 8, 2024 [PDF](https://www.o8t.com/research#) ###### [Eloquent noneloquence: redefinition of cortical eloquence based on outcomes of superficial cerebral cavernous malformation resection](https://www.o8t.com/hubfs/Clinical%20Papers/Eloquent%20noneloquence%20-%20redefinition%20of%20cortical%20eloquence.pdf?hsLang=en) Quicktome's connectomic analysis on brain malformation surgery exposed 7 unforeseen eloquent regions, highlighting the need for refined surgical strategies and a broader definition of cortical... Clinical investigation January 6, 2024 [PDF](https://www.o8t.com/research#) ###### [Connectome-Based Neurosurgery in Primary Intra-Axial Neoplasms](https://www.o8t.com/hubfs/Clinical%20Papers/Magnani%202024%20Connectome-Based%20Neurosurgery.pdf?hsLang=en) Despite advances in surgical treatments for brain tumors improving survival, connectomics enables a nuanced focus on preserving patients' neurocognitive functions and life reintegration. Clinical investigation October 1, 2023 [PDF](https://www.o8t.com/research#) ###### [Incorporation of Brain Connectomics for Stereotactic Radiosurgery Treatment Planning](https://www.o8t.com/hubfs/Clinical%20Papers/Sheehan%20-%20Incorporation%20of%20Brain%20Connectomics%20for%20Stereotactic%20Radiosurgery%20Treatment%20Planning%202023.pdf?hsLang=en) Neurosurgeons incorporated connectomes into radiosurgical planning, enabling safer dose delivery by protecting crucial brain networks in a patient's AVM treatment. Clinical investigation August 7, 2023 [Website page](https://www.o8t.com/research#) ###### [Connectomics as a prognostic tool of functional outcome in glioma surgery of the supplementary motor area: illustrative case](https://thejns.org/caselessons/view/journals/j-neurosurg-case-lessons/6/6/article-CASE23286.xml) Comparison of the pre- and postoperative connectome can be used to objectively evaluate surgical outcomes and assess patient prognosis. To the best of the authors’ knowledge, this is the first case... Neuropathology July 6, 2023 [Website page](https://www.o8t.com/research#) ###### [Connectomic insight into unique stroke patient recovery after rTMS treatment](https://www.frontiersin.org/articles/10.3389/fneur.2023.1063408/full) Using machine learning, individual brain connectivity analyses reveal unique recovery paths in stroke patients post-treatment. Clinical investigation June 1, 2023 [PDF](https://www.o8t.com/research#) ###### [Case Study: Intraoperative awake language mapping correlates to preoperative connectomics imaging: An instructive case](https://www.o8t.com/hubfs/Clinical%20Papers/Shah%2c%20DAmico%2c%20Silverstein%202023%20-%20%20Intraoperative%20awake%20language%20mapping%20correlates%20to%20preoperative%20connectomics%20imaging-%20an%20instructive%20case.pdf?hsLang=en) Quicktome revealed functional regions at risk of damage during resection, and it correlated to intraoperative language mapping findings. Novel analytic techniques March 22, 2023 [Website page](https://www.o8t.com/research#) ###### [An agile, data driven approach for target selection in rTMS therapy for anxiety symptoms: Proof of concept and preliminary data for two novel targets](https://onlinelibrary.wiley.com/doi/10.1002/brb3.2914) Analysed anomaly patterns in anxiety patients, revealing that the default mode network (DMN) is likely the primary network disturbed in anxiety-related disorders. Novel analytic techniques March 16, 2023 [Website page](https://www.o8t.com/research#) ###### [Real World Demonstration of Hand Motor Mapping using the Structural Connectivity Atlas](https://www.sciencedirect.com/science/article/abs/pii/S0303846723000951) Found the SCA to be a viable option for pre-surgical planning and general clinical use. Neuroanatomy March 13, 2023 [Website page](https://www.o8t.com/research#) ###### [Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect non-visual cerebrum to the lateral occipital lobe](https://onlinelibrary.wiley.com/doi/10.1002/brb3.2945?utm_campaign=People%20%26%20Culture&utm_medium=email&_hsmi=250904664&_hsenc=p2ANqtz-_ZnBDVPn8JMnkuMg1PaPAX_WIMmWPYDr-5uJbWnWqkp7a22X0J8to4yGp1MqdFGSxYnhcmDr4TYH0WZU8h0Oxz1kfCww&utm_content=250904664&utm_source=hs_email) We mapped the visual network and found interesting insights on its role in non-visual connections. Clinical investigation February 26, 2023 [Website page](https://www.o8t.com/research#) ###### [Symptom-Circuit Mappings of the Schizophrenia Connectome](https://www.sciencedirect.com/science/article/abs/pii/S0165178123000756?via%3Dihub) Conducted in collaboration with Shanghai Mental Health Centre, we modelled the anatomical circuits underlying schizophrenia symptoms. Neuropathology February 24, 2023 [Website page](https://www.o8t.com/research#) ###### [Functional connectivity analysis of the depression connectome provides potential markers and targets for transcranial magnetic stimulation](https://www.o8t.com/hubfs/Clinical%20Papers/Functional%20connectivity%20analysis%20of%20the%20depression%20connectome%20provides%20potential%20markers%20and%20targets%20for%20transcranial%20magnetic%20stimulation.pdf?hsLang=en) Joint study with Monash University compares functional connectivity patterns in TMS responders vs non-responders for MDD treatment. Machine learning identified potential treatment targets. Neuropathology February 15, 2023 [Website page](https://www.o8t.com/research#) ###### [Connectomics underlying motor functional outcomes in the acute period following stroke](https://www.frontiersin.org/articles/10.3389/fnagi.2023.1131415/full) Demonstrates how connectomics can be a valuable asset in stroke management when used in predictive modelling of neuro-rehabilitation outcomes. Neuropathology January 31, 2023 [PDF](https://www.o8t.com/research#) ###### [Letter to the editor: Standardizing connectome-based brain tumor surgery through a network-based surgical nomenclature](https://www.o8t.com/hubfs/Clinical%20Papers/Standardizing%20connectome%E2%80%90based%20brain%20tumor%20surgery%20through%20a%20network%E2%80%90based%20surgical%20nomenclat.pdf?hsLang=en) The correspondence describes a novel scale (the "Sughrue-Ivan" scale) to describe a tumour's location and risk relative to large-scale brain networks. Novel analytic techniques January 16, 2023 [PDF](https://www.o8t.com/research#) ###### [Review: Graph Theory Measures and Their Application to Neurosurgical Eloquence](https://www.mdpi.com/2072-6694/15/2/556) Through graphically representing the brain, mathematical graph theory approaches may be able to provide additional information on important inter-individual network properties and functionally... Neuroanatomy January 1, 2023 [PDF](https://www.o8t.com/research#) ###### [Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity](https://www.o8t.com/hubfs/Clinical%20Papers/Connectivity%20model%20of%20the%20anatomic%20substrates%20and%20network%20abnormalities%20in%20major%20depressive%20disorder%20-%20A%20coordinate%20meta-analysis%20of%20resting-state%20functional%20connectivity.pdf?hsLang=en) Meta-analysis of functional connectivity in MDD suggests abnormal interactions between brain networks, particularly increased default mode-central executive pairs and decreased default mode-other... Neuropathology September 19, 2022 [Website page](https://www.o8t.com/research#) ###### [Using machine learning to evaluate large-scale brain networks in patients with brain tumors: Traditional and non-traditional eloquent areas](https://www.o8t.com/hubfs/Clinical%20Papers/Morell%20et%20al%202022%20Using%20machine%20learning%20to%20evaluate%20large-scale%20brain%20networks.pdf?hsLang=en) A retrospective analysis of 100 brain tumor surgery patients using Quicktome. Quicktome showed the extensive involvement of non-traditional networks around regions of pathology that would not... Clinical investigation August 10, 2022 [PDF](https://www.o8t.com/research#) ###### [Connectomic disturbances underlying insomnia disorder and predictors of treatment response](https://www.o8t.com/hubfs/Clinical%20Papers/Connectomic%20disturbances%20underlying%20insomnia%20disorder%20and%20predictors%20of%20treatment%20response.pdf?hsLang=en) A high powered prospective study comparing healthy individuals and insomnia patients revealed Connectomic changes in the DMN and associated networks underlying the severity of the disorder. Neuroanatomy August 5, 2022 [PDF](https://www.o8t.com/research#) ###### [Minimally invasive keyhole techniques for resection of giant intracranial tumors](https://www.o8t.com/hubfs/Clinical%20Papers/Minimally%20invasive%20keyhole%20techniques%20for%20resection%20of%20giant%20intracranial%20tumors.pdf?hsLang=en) This retrospective investigation of 95 patients operated on between 2012-2017 advocates for the safety of keyhole approaches for removal of giant intracranial tumors. Clinical investigation June 14, 2022 [PDF](https://www.o8t.com/research#) ###### [A connectivity model of the anatomic substrates underlying Gerstmann syndrome](https://www.o8t.com/hubfs/Clinical%20Papers/Gerstmann%20syndrome.pdf?hsLang=en) Gerstmann syndrome is a neurological phenomena associated with a variety of motor and cognitive deficits. From a large clinical dataset, we identify brain networks compromised in this syndrome. Novel analytic techniques May 14, 2022 [Website page](https://www.o8t.com/research#) ###### [Prehabilitation and rehabilitation using data-driven, parcel-guided transcranial magnetic stimulation treatment for brain tumor surgery: proof of concept case report](https://www.o8t.com/hubfs/Clinical%20Papers/Prehabilitation%20and%20rehabilitation.pdf?hsLang=en) A case review demonstrating the utility of o8t software alongside neurorehabilitation to assess functional recovery after glioma removal. Neuropathology May 3, 2022 [PDF](https://www.o8t.com/research#) ###### [Machine Learning Decomposition of the Anatomy of Neuropsychological Deficit in Alzheimer’s Disease and Mild Cognitive Impairment](https://www.o8t.com/hubfs/Clinical%20Papers/Machine%20Learning%20Decomposition%20of%20the%20Anatomy%20of%20Neuropsychological%20Deficit%20in%20Alzheimer%E2%80%99s%20Disease%20and%20Mild%20Cognitive%20Impairment.pdf?hsLang=en) The Hollow Tree Super (HoTS) method was applied to a patient and healthy control group to define parcels and networks corresponding with diagnosis of MCI and Alzheimers. Novel analytic techniques May 3, 2022 [PDF](https://www.o8t.com/research#) ###### [12 Plagues of AI in Healthcare: A Practical Guide to Current Issues With Using Machine Learning in a Medical Context](https://www.o8t.com/hubfs/Clinical%20Papers/12%20Plagues%20of%20AI%20in%20Healthcare%20A%20Practical%20Guide%20to%20Current%20Issues%20With%20Using%20Machine%20Learning%20in%20a%20Medical%20Context.pdf?hsLang=en) A review of the current applications of Machine Learning and AI in health science data, and how users can avoid common mistakes when handling data. Neuropathology April 14, 2022 [Website page](https://www.o8t.com/research#) ###### [Early Experience Using Omniscient Neurotechnology Fiber Tracking Software for Resection of Intra-Axial Brain Tumors](https://www.o8t.com/hubfs/Clinical%20Papers/Early%20Experience%20Using%20Omniscient%20Neurotechnology%20Fiber%20Tracking%20Software%20for%20Resection%20of%20Intra-Axial%20Tumors.pdf?hsLang=en) A report on single-center experience using Quicktome for resection of intra-axial brain tumors Neuropathology April 6, 2022 [PDF](https://www.o8t.com/research#) ###### [Should Neurosurgeons Try to Preserve Non-Traditional Brain Networks? A Systematic Review of the Neuroscientific Evidence](https://www.o8t.com/hubfs/Clinical%20Papers/Should%20neurosurgeons%20avoid%20non-eloquent%20networks%202022.pdf?hsLang=en) A meta-analytic approach revealing the cognitive and emotional consequences of damaging brain networks in neurosurgery. Neuroanatomy March 25, 2022 [PDF](https://www.o8t.com/research#) ###### [Transcranial magnetic stimulation for post-operative neurorehabilitation in neuro-oncology: a review of the literature and future directions](https://www.o8t.com/hubfs/Clinical%20Papers/TMS%20review%202022.pdf?hsLang=en) A retrospective assessment of the recent progression in clinical utility of Transcranial Magnetic Stimulation (TMS). The end goal of a patient-specific application is discussed. Neuropathology March 8, 2022 [PDF](https://www.o8t.com/research#) ###### [Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005-2014](https://www.o8t.com/hubfs/Clinical%20Papers/LGG%20mental%20health%202022.pdf?hsLang=en) A formal investigation of the prevalence of co-morbid mental health disorders following Glioma diagnosis between 2005-2014 Clinical investigation February 23, 2022 [PDF](https://www.o8t.com/research#) ###### [Interventional neurorehabilitation for promoting functional recovery post‑craniotomy: a proof‑of‑concept](https://www.o8t.com/hubfs/Clinical%20Papers/Interventional%20Neurorehabilitation%20for%20promoting%20functional%20recovery%20post-craniotomy.pdf?hsLang=en) A proof-of-concept study demonstrating the capability of o8t software in generating personalized TMS targets for post-craniotomy neurorehabilitation Novel analytic techniques February 4, 2022 [PDF](https://www.o8t.com/research#) ###### [Eigenvector PageRank difference as a measure to reveal topological characteristics of the brain connectome for neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Eigenvector%20PageRank%202022.pdf?hsLang=en) An investigation of two graph theory metrics: Eigenvector and PageRank centrality, and how they together inform unique and neurosurgically meaningful topological characteristics of the brain Neuropathology January 17, 2022 [PDF](https://www.o8t.com/research#) ###### [Patterns of Traditional and Nontraditional Network Involvement in Insulo-Sylvian Gliomas: An Anatomic Study using the Quicktome Platform](https://www.o8t.com/hubfs/Clinical%20Papers/Patterns%20of%20Traditional%20and%20Nontraditional%20Network%20Involvement%20in%20Insulo-Sylvian%20Gliomas.pdf?hsLang=en) A retrospective investigation using Quicktome to demonstrate brain networks compromised by Glioma. Novel analytic techniques November 28, 2021 [PDF](https://www.o8t.com/research#) ###### [Connectivity-based parcellation of normal and anatomically distorted human cerebral cortex](https://www.o8t.com/hubfs/Clinical%20Papers/Doyen%20et%20al.%2c%202021%20SCA%20full%20text.pdf?hsLang=en) As the basis for the creation of our patient-specific brain maps, this manuscript unveils the Structural Connectivity Atlas (SCA) methodology Neuroanatomy November 28, 2021 [PPT](https://www.o8t.com/research#) ###### [Connectivity-based parcellation of normal and anatomically distorted human cerebral cortex](https://www.o8t.com/hubfs/Clinical%20Papers/Doyen%20et%20al.%2c%202021%20SCA%20full%20text.pdf?hsLang=en) As the basis for the creation of our patient-specific brain maps, this manuscript unveils the Structural Connectivity Atlas (SCA) methodology Neuropathology October 28, 2021 [PDF](https://www.o8t.com/research#) ###### [Changes in the Brain Connectome Following Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation](https://www.o8t.com/hubfs/Clinical%20Papers/Yeung%20et%20al.%2c%202021%20Connectome%20following%20rTMS.pdf?hsLang=en) In this case report, we use Infinitome to find optimal targets for rTMS in a patient who had suffered an Ischemic Stroke. Neuroanatomy August 26, 2021 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the precuneus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20precuneus.pdf?hsLang=en) The Precuneus is involved in visuospatial processing and cognition. We reveal the major connections and functions of the precuneus. Neuropathology August 16, 2021 [PDF](https://www.o8t.com/research#) ###### [Reducing the cognitive footprint of brain tumor surgery ](https://www.o8t.com/hubfs/Clinical%20Papers/Dadario%20et%20al.%2c%202021%20Reducing%20the%20cognitive%20footprint.pdf?hsLang=en) This paper conceptualizes modern neurosurgical approaches from eloquence to centrality. We break down the major breakthroughs in the field which may benefit patient onco-functional balance. Neuropathology August 13, 2021 [PDF](https://www.o8t.com/research#) ###### [Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept](https://www.o8t.com/hubfs/Clinical%20Papers/Yeung%20et%20al.%2c%202021%20Using%20Quicktome%20for%20Intracerebral%20Surgery.pdf?hsLang=en) Using Quicktome, our team re-examined cases of intracerebral surgery and demonstrated a machine-learning approach to investigating the organization of compromised brain networks. Novel analytic techniques August 13, 2021 [PPT](https://www.o8t.com/research#) ###### [Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept](https://www.o8t.com/hubfs/Clinical%20Papers/Yeung%20et%20al.%2c%202021%20Using%20Quicktome%20for%20Intracerebral%20Surgery.pdf?hsLang=en) Using Quicktome, our team re-examined cases of intracerebral surgery and demonstrated a machine-learning approach to investigating the organization of compromised brain networks. Clinical investigation June 15, 2021 [PDF](https://www.o8t.com/research#) ###### [A Connectivity Model of the Anatomic Substrates Underlying Ideomotor Apraxia A Meta-Analysis of Functional Neuroimaging Studies](https://www.o8t.com/hubfs/Clinical%20Papers/A%20%20Connectivity%20%20Model%20%20of%20%20the%20%20Anatomic%20%20Substrates%20Underlying%20%20Ideomotor%20%20Apraxia%20%20A%20%20Meta-Analysisof%20%20Functional%20%20Neuroimaging%20%20Studies.pdf?hsLang=en) A meta-analysis revealing the network constitutents of ideomotor apraxia. We present a connectivity model to explain the determinants of this condition. Neuroanatomy June 15, 2021 [PPT](https://www.o8t.com/research#) ###### [A Connectivity Model of the Anatomic Substrates Underlying Ideomotor Apraxia A Meta-Analysis of Functional Neuroimaging Studies](https://www.o8t.com/hubfs/Clinical%20Papers/A%20%20Connectivity%20%20Model%20%20of%20%20the%20%20Anatomic%20%20Substrates%20Underlying%20%20Ideomotor%20%20Apraxia%20%20A%20%20Meta-Analysisof%20%20Functional%20%20Neuroimaging%20%20Studies.pdf?hsLang=en) A meta-analysis revealing the network constitutents of ideomotor apraxia. We present a connectivity model to explain the determinants of this condition. Neuroanatomy April 21, 2021 [PDF](https://www.o8t.com/research#) ###### [Anatomy and White Matter Connections of the Lingual Gyrus and Cuneus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20White%20Matter%20Connections%20of%20the%20Lingual%20Gyrus%20and%20Cuneus.pdf?hsLang=en) The medial occipital lobe, composed of the lingual gyrus and cuneus, is necessary for basic and higher level visual processing. We investigate the connections of the medial occipital lobe. Novel analytic techniques April 7, 2021 [PDF](https://www.o8t.com/research#) ###### [Hollow-tree Super: a directional and scalable approach for feature importance in boosted tree models](https://www.o8t.com/hubfs/Clinical%20Papers/Hollow-tree%20super_%20A%20directional%20and%20scalable%20approach%20for%20feature%20importance%20in%20boosted%20tree%20models%20_.pdf?hsLang=en) This manuscript unveils a novel method for investigating which brain regions are most responsible for greater scores on psychometric tests such as the PANSS for Schizophrenia - Hollow Tree Super. Clinical investigation April 6, 2021 [PDF](https://www.o8t.com/research#) ###### [Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation](https://www.o8t.com/hubfs/Clinical%20Papers/Akinetic%20mutism%20reversed%20by%20inferior%20parietal%20lobule%20repetitive%20theta%20burst%20stimulation.pdf?hsLang=en) A case study highlighting the benefits of transcranial magnetic stimulation for restoring network functional connectivity in the DMN. Clinical investigation April 1, 2021 [PDF](https://www.o8t.com/research#) ###### [Targeting location relates to treatment response in active but not sham rTMS stimulation](https://www.o8t.com/hubfs/Clinical%20Papers/Targeting%20Location%20Relates%20to%20Treatment%20Response%20in%20Active%20but%20not%20Sham%20rTMS%20Stimulation.pdf?hsLang=en) A re-opened investigation utilizing o8t atlassing revealed that inaccurate targeting of the dlPFC in veterans reduced treatment response. Neuroanatomy March 19, 2021 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the superior parietal lobule](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20superior%20parietal%20lobule.pdf?hsLang=en) The superior parietal lobule (SPL) is involved in somatosensory and visuospatial integration. We reveal the cortical constituents and connections of the SPL. Neuroanatomy March 17, 2021 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the middle frontal gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20middle%20frontal%20gyrus.pdf?hsLang=en) The Middle Frontal Gyrus (MFG) is involved in attention processing and working memory. We reveal the major connections and functions of the MFG. Neuroanatomy March 10, 2021 [PDF](https://www.o8t.com/research#) ###### [A cortical based analysis of ventral premotor area connectivity](https://www.o8t.com/hubfs/Clinical%20Papers/A%20cortical%20parcellation%20based%20analysis%20of%20ventral%20premotor%20area%20connectivity.pdf?hsLang=en) The Ventral Premotor Area (VPM) is involved in motor control and execution. We reveal the major connections and functions of the VPM. Neuropathology March 5, 2021 [PDF](https://www.o8t.com/research#) ###### [The Frontal Aslant Tract and Supplementary Motor Area Syndrome: Moving towards a Connectomic Initiation Axis](https://www.o8t.com/hubfs/Clinical%20Papers/The%20Frontal%20Aslant%20Tract%20and%20Supplementary%20Motor%20Area%20Syndrome%20Moving%20towards%20a%20Connectomic%20Initiation%20Axis.pdf?hsLang=en) This study provides a retrospective investigation of the utility of Diffusion Tensor Imaging (DTI) for neurosurgical planning of medial frontal gliomas. Novel analytic techniques March 5, 2021 [PPT](https://www.o8t.com/research#) ###### [The Frontal Aslant Tract and Supplementary Motor Area Syndrome: Moving towards a Connectomic Initiation Axis](https://www.o8t.com/hubfs/Clinical%20Papers/The%20Frontal%20Aslant%20Tract%20and%20Supplementary%20Motor%20Area%20Syndrome%20Moving%20towards%20a%20Connectomic%20Initiation%20Axis.pdf?hsLang=en) This study provides a retrospective investigation of the utility of Diffusion Tensor Imaging (DTI) for neurosurgical planning of medial frontal gliomas. Neuroanatomy February 3, 2021 [PDF](https://www.o8t.com/research#) ###### [The Unique Fiber Anatomy of Middle Temporal Gyrus Default Mode Connectivity](https://www.o8t.com/hubfs/Clinical%20Papers/The%20Unique%20Fiber%20Anatomy%20of%20Middle%20Temporal%20Gyrus%20Default%20Mode%20Connectivity.pdf?hsLang=en) The middle temporal gyrus (MTG) is understood to play a role in language related tasks. We investigate the cortical connections and components of the MTG. Neuroanatomy January 18, 2021 [PDF](https://www.o8t.com/research#) ###### [Parcellation-based modeling of the supplementary motor area](https://www.o8t.com/hubfs/Clinical%20Papers/Parcellation-based%20modeling%20of%20the%20supplementary%20premotor%20area.pdf?hsLang=en) The supplementary motor area (SMA) plays a role in the initiation of internally and externally cued movements. This manuscript investigates the cortical connections of the SMA. Neuroanatomy January 4, 2021 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the parahippocampal gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20parahippocampal%20gyrus.pdf?hsLang=en) The Parahippocampal Gyrus (PHG) is involved in memory encoding and cognition. We reveal the major connections and functions of the PHG. Neuropathology December 11, 2020 [PDF](https://www.o8t.com/research#) ###### [Navigated transcranial magnetic stimulation following awake craniotomy for resection of glioma: Description of two cases](https://www.o8t.com/hubfs/Clinical%20Papers/Navigated%20transcranial%20magnetic%20stimulation%20for%20awake%20craniotomy%20for%20resection%20of%20glioma.pdf?hsLang=en) This dual case study reports on the use of theta burst stimulation (cTBS) for postoperative strategy following brain tumor resection. Clinical investigation November 23, 2020 [PDF](https://www.o8t.com/research#) ###### [Application of structural and functional connectome mismatch for classification and individualized therapy for Alzheimers disease](https://www.o8t.com/hubfs/Clinical%20Papers/Application%20of%20structural%20and%20functional%20connectome%20mismatch%20for%20classification%20and%20individualized%20therapy%20for%20alzheimer%20disease.pdf?hsLang=en) By utilizing the o8t Infinitome processing pipeline, this study revealed connectomic anomalies in the Default Mode Network (DMN) which underpinned the progression of Alzheimer's Disease. Neuroanatomy November 15, 2020 [PDF](https://www.o8t.com/research#) ###### [ Parcellation-based anatomic modelling of the default mode network](https://www.o8t.com/hubfs/Clinical%20Papers/DMN%20Neuroanat.pdf?hsLang=en) The default mode network (DMN) is an important mediator of passive states of mind. We investigate the cortical areas which constitute the DMN. Neuropathology November 4, 2020 [PDF](https://www.o8t.com/research#) ###### [Unexpected hubness: a proof‑of‑concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Yeung%20et%20al.%202020%20Unexpected%20Hubness.pdf?hsLang=en) By utilizing PageRank Centrality, a common algorithm for search engine optimization, we investigated the remapping of neural hubs in individuals suffering from Schizophrenia. Novel analytic techniques November 4, 2020 [PPT](https://www.o8t.com/research#) ###### [Unexpected hubness: a proof‑of‑concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Yeung%20et%20al.%202020%20Unexpected%20Hubness.pdf?hsLang=en) By utilizing PageRank Centrality, a common algorithm for search engine optimization, we investigated the remapping of neural hubs in individuals suffering from Schizophrenia. Neuroanatomy September 11, 2020 [PDF](https://www.o8t.com/research#) ###### [A parcellation-based model of the auditory network](https://www.o8t.com/hubfs/Clinical%20Papers/Pacellation%20based%20model%20of%20the%20auditory%20network.pdf?hsLang=en) Many cortical areas co-ordinate human's auditory sense. We present a tractographic model of the brain's primary auditory network Neuropathology September 1, 2020 [PDF](https://www.o8t.com/research#) ###### [Pure Apraxia of Speech After Resection Based in the Posterior Middle Frontal Gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Pure%20Apraxia%20of%20speech%20after%20resection%20based%20in%20the%20posterior%20middle%20frontal%20gyrus.pdf?hsLang=en) We present a surgical case study outlining a surgical anomaly: where resection of a tumor in the posterior middle frontal gyrus resulted in pure speech apraxia. Neuroanatomy August 10, 2020 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the fusiform gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Fusiform%20Gyrus.pdf?hsLang=en) The fusiform gyrus is understood to be involved in the processing of high-order visual information. We characterize its connections by anatomical dissection and fibre tractography. Neuropathology July 31, 2020 [PDF](https://www.o8t.com/research#) ###### [The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/The%20cortical%20organization%20of%20language%20distilling%20human%20connectome%20insights%20for%20supratentorial%20neurosurgery.pdf?hsLang=en) Connectomic approaches have bolstered surgical understanding of the brains major language networks. This manuscript summarizes and reviews these major advancements. Neuroanatomy July 31, 2020 [PPT](https://www.o8t.com/research#) ###### [The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/The%20cortical%20organization%20of%20language%20distilling%20human%20connectome%20insights%20for%20supratentorial%20neurosurgery.pdf?hsLang=en) Connectomic approaches have bolstered surgical understanding of the brains major language networks. This manuscript summarizes and reviews these major advancements. Neuroanatomy May 17, 2020 [PDF](https://www.o8t.com/research#) ###### [Parcellation-based modelling of the dorsal premotor area](https://www.o8t.com/hubfs/Clinical%20Papers/Parcellation-based%20modeling%20of%20the%20dorsal%20premotor%20area.pdf?hsLang=en) This manuscript investigates the cortical connections of the Dorsal Premotor Area (DPM), a critical region for coordinating hand muscle recruitment for motor tasks such as grasping and lifting. Novel analytic techniques January 1, 2020 [PDF](https://www.o8t.com/research#) ###### [Beyond eloquence and onto centrality: a new paradigm in planning supratentorial neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Beyond%20Eloquence%20And%20Onto%20Centrality%20a%20new%20paradigm%20in%20planning%20supratentorial%20neurosurgery.pdf?hsLang=en) In this study we explore whether centrality metrics can be utilized to inform the location of surgically eloquent regions. We found PageRank centrality reliably predicted surgically eloquent. Neuropathology January 1, 2020 [PPT](https://www.o8t.com/research#) ###### [Beyond eloquence and onto centrality: a new paradigm in planning supratentorial neurosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Beyond%20Eloquence%20And%20Onto%20Centrality%20a%20new%20paradigm%20in%20planning%20supratentorial%20neurosurgery.pdf?hsLang=en) In this study we explore whether centrality metrics can be utilized to inform the location of surgically eloquent regions. We found PageRank centrality reliably predicted surgically eloquent. Neuroanatomy November 21, 2019 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the Superior Frontal Gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20superior%20frontal%20gyrus%202.pdf?hsLang=en) By corroborating tractographic mapping with gross anatomic dissection, we characterize fiber tracts of the Superior Frontal Gyrus (SFG) based on their relationships to known neuroanatomic structures. Neuroanatomy November 16, 2019 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the lateral occipital cortex](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20lateral%20occipital%20cortex.pdf?hsLang=en) The lateral occipital lobe plays a role in object recognition, facial recognition, and motion perception. This manuscript investigates the cortical connections of the lateral occipital lobe. Neuroanatomy October 24, 2019 [PDF](https://www.o8t.com/research#) ###### [Parcellation-based tractographic modelling of the ventral attention network](https://www.o8t.com/hubfs/Clinical%20Papers/Parcellation-based%20tractographic%20modeling%20of%20the%20ventral%20attention%20network.pdf?hsLang=en) The ventral attention network (VAN) is an important mediator of stimulus-driven attention. We investigate the cortical areas which constitute the VAN. Clinical investigation October 10, 2019 [PDF](https://www.o8t.com/research#) ###### [Bilateral carotid-cavernous fistulas treated with partial embolization and radiosurgery](https://www.o8t.com/hubfs/Clinical%20Papers/Bilateral%20carotid-cavernous%20fistulas%20treated%20with%20partial%20embolization%20and%20radiosurgery.pdf?hsLang=en) This manuscript presents a case report, treatment strategy, and subsequent outcomes of a patient suffering a rare bilateral carotid-cavernous fistula (CCF). Novel analytic techniques October 9, 2019 [PDF](https://www.o8t.com/research#) ###### [Measuring graphical strength within the connectome: a neuroanatomic, parcellation-based study](https://www.o8t.com/hubfs/Clinical%20Papers/Measuring%20graphical%20strength%20in%20the%20connectome.pdf?hsLang=en) This study explores the use common graph theory metrics for defining functionally important areas of the cortex. Those we identified heavily overlapped with those known to be surgically eloquent. Neuroanatomy May 23, 2019 [PDF](https://www.o8t.com/research#) ###### [Parcellation-based tractographic modelling of the dorsal attention network](https://www.o8t.com/hubfs/Clinical%20Papers/Parcellation-based_tractographic_modeling_of_the_dorsal%20attention%20network.pdf?hsLang=en) The dorsal attention network (DAN) is an important mediator of goal‐ directed attentional processing. We investigate the cortical areas which constitute the DAN. Neuroanatomy February 28, 2019 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the Inferior Frontal Gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20White%20Matter%20Connections%20of%20the%20Inferior%20Frontal%20Gyrus.pdf?hsLang=en) By corroborating tractographic mapping with gross anatomic dissection, we characterize fiber tracts of the Inferior Frontal Gyrus (IFG) based on their relationships to known neuroanatomic structures. Neuropathology January 1, 2019 [PDF](https://www.o8t.com/research#) ###### [Macroconnectomic networks of the human brain](https://www.o8t.com/hubfs/Clinical%20Papers/Macroconnectomic%20networks%20of%20the%20human%20brain.pdf?hsLang=en) As part of a larger book on surgical management, this chapter discusses the functional organization of brain networks. Neuroanatomy January 1, 2019 [PPT](https://www.o8t.com/research#) ###### [Macroconnectomic networks of the human brain](https://www.o8t.com/hubfs/Clinical%20Papers/Macroconnectomic%20networks%20of%20the%20human%20brain.pdf?hsLang=en) As part of a larger book on surgical management, this chapter discusses the functional organization of brain networks. Neuropathology December 6, 2017 [PDF](https://www.o8t.com/research#) ###### [The crossed frontal aslant tract: a possible pathway involved in the recovery of supplementary motor area syndrome](https://www.o8t.com/hubfs/Clinical%20Papers/The%20crossed%20frontal%20aslant%20tract%20a%20possible%20pathway%20involved%20in%20the%20recovery%20of%20supplementary%20motor%20area%20syndrome.pdf?hsLang=en) We present a novel hypothesis for the manifestation of Supplementary Motor Area (SMA) syndrome: that damaging the crossed frontal aslant tract subsists this neurosurgical consequence. Clinical investigation December 6, 2017 [PPT](https://www.o8t.com/research#) ###### [The crossed frontal aslant tract: a possible pathway involved in the recovery of supplementary motor area syndrome](https://www.o8t.com/hubfs/Clinical%20Papers/The%20crossed%20frontal%20aslant%20tract%20a%20possible%20pathway%20involved%20in%20the%20recovery%20of%20supplementary%20motor%20area%20syndrome.pdf?hsLang=en) We present a novel hypothesis for the manifestation of Supplementary Motor Area (SMA) syndrome: that damaging the crossed frontal aslant tract subsists this neurosurgical consequence. Neuropathology October 16, 2017 [PDF](https://www.o8t.com/research#) ###### [Common Disconnections in Glioma Surgery: An Anatomic Description](https://www.o8t.com/hubfs/Clinical%20Papers/Common%20disconnections%20in%20glioma%20surgery.pdf?hsLang=en) This manuscript offers expert advice on neurosurgical approaches for glioma removal in the cortex, including how best to preserve eloquent brain regions and their connections. Neuroanatomy March 23, 2017 [PDF](https://www.o8t.com/research#) ###### [Anatomy and white matter connections of the Orbitofrontal Gyrus](https://www.o8t.com/hubfs/Clinical%20Papers/Anatomy%20and%20white%20matter%20connections%20of%20the%20orbitofrontal%20gyrus.pdf?hsLang=en) The orbitofrontal cortex (OFC) is understood to have a role in outcome evaluation and risk assessment. We characterize the connections of the OFC by anatomical dissection and fibre tractography. Neuroanatomy December 20, 2016 [PDF](https://www.o8t.com/research#) ###### [White matter connections of the inferior parietal lobule: A study of surgical anatomy](https://www.o8t.com/hubfs/Clinical%20Papers/Inferior%20parietal%20lobule.pdf?hsLang=en) By corroborating tractographic mapping with anatomic dissection, we characterize fiber tracts of the Inferior Parietal Lobule (IPL) based on their relationships to known neuroanatomic structures. Neuropathology December 20, 2016 [PPT](https://www.o8t.com/research#) ###### [White matter connections of the inferior parietal lobule: A study of surgical anatomy](https://www.o8t.com/hubfs/Clinical%20Papers/Inferior%20parietal%20lobule.pdf?hsLang=en) By corroborating tractographic mapping with anatomic dissection, we characterize fiber tracts of the Inferior Parietal Lobule (IPL) based on their relationships to known neuroanatomic structures. Neuropathology December 16, 2016 [PDF](https://www.o8t.com/research#) ###### [A simplified method of accurate postprocessing of diffusion tensor imaging for use in brain tumor resection](https://www.o8t.com/hubfs/Clinical%20Papers/A%20simplified%20method%20of%20accurate%20postprocessing%20of%20diffusion%20tensor%20imaging%20for%20use%20in%20brain%20tumor%20resection.pdf?hsLang=en) By assessing the operative results of 43 craniotomy patients, we report on the use and benefit of DTI implementation in surgical workflows. Novel analytic techniques December 16, 2016 [PPT](https://www.o8t.com/research#) ###### [A simplified method of accurate postprocessing of diffusion tensor imaging for use in brain tumor resection](https://www.o8t.com/hubfs/Clinical%20Papers/A%20simplified%20method%20of%20accurate%20postprocessing%20of%20diffusion%20tensor%20imaging%20for%20use%20in%20brain%20tumor%20resection.pdf?hsLang=en) By assessing the operative results of 43 craniotomy patients, we report on the use and benefit of DTI implementation in surgical workflows. ## Other Resources ###### SIUU Learn more about our commitment to transparency and truthfulness in the medical literature we share.  [Explore ](https://www.o8t.com/siuu?hsLang=en) ###### Blog Explore our blog to learn more about Connectomics, brain mapping and more. [Explore ](https://www.o8t.com/blog?hsLang=en) ###### Case Studies View cases as seen in Quicktome. 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